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Genomic Second Opinion for Complex and Blended Phenotypes

We offer clinical-grade whole exome or whole genome DNA sequencing data interpretation.

For Patients

For patients with unexplained neurological, developmental, psychiatric or multisystem symptoms, we provide physician-supervised genomic interpretation that converts sequencing data and clinical history into a prioritized genomic differential diagnosis, pharmacogenomic report, and practical next-step plan for discussion with the treating clinician.

Discover how your genetic test results can reveal health risks—heart disease, cancer, or blood sugar problems—and learn what to do next.

For Clinicians

We help clinicians interpret complex genomic data in patients who remain undiagnosed after standard evaluation. Our reports prioritize candidate diagnoses, links findings in the clinical history, identifies confirmatory tests and referrals, and includes a pharmacogenomic medication risk report.

Contact us for more information

Are you a patient or a physician?*

Had genetic testing but still no answers? We specialize in clinically focused reinterpretation to uncover what matters for your health.

What We Do

We identify disease-causing pathogenic variants following ACMG guidelines.

Our Technology here

Who We Are

Founded by a practicing physician with expertise in bioinformatics and genomics.

Read About Us here

The Benefits

Our reports enable your healthcare provider to streamline medical follow-ups, tests, and referrals, enhancing your treatment and disease prevention.

Sample Report here

A few MORE things we’re great at

Comprehensive Genetic Testing for 15,000+ Conditions

Asperger’s Syndrome, Autism Spectrum Disorders

Nonverbal Autism
Asperger’s Syndrome
Pervasive Developmental Disorder Not Otherwise Specified (PDD-NOS)
Childhood Disintegrative Disorder

ADHD, Severe Anxiety, Treatment-Resistant Depression

Attention Deficit Hyperactivity Disorder (ADHD)
Generalized Anxiety Disorder (GAD)
Obsessive-Compulsive Disorder (OCD)
Persistent Major Depressive Disorder (MDD)
Bipolar Disorder with Treatment-Resistant Depression

Cases Where Medications Are Ineffective or Cause Severe Side Effects

Pharmacogenomic Issues (e.g., variations in enzymes affecting drug metabolism)
Adverse Drug Reactions (e.g., Stevens-Johnson Syndrome, Drug-Induced Lupus)
Multiple Drug Allergies or Sensitivities

Genetic Risk for Alzheimer’s: APOE Genotype

Are you experiencing unexplained memory loss? Family history of dementia? Let MoodNote Genomics help you find the answers you need to start feeling better. Take your APOE genotype test today as the first step towards a healthier you.

Seizures

Down Syndrome
Fragile X Syndrome
Rett Syndrome
Lennox-Gastaut Syndrome
Dravet Syndrome

Skin, Sensory, or Digestive Issues

Eczema (Atopic Dermatitis)
Psoriasis
Sensory Processing Disorder
Irritable Bowel Syndrome (IBS)
Crohn’s Disease
Celiac Disease

Why Choose Us?

Most sequencing services rely on software engineers — we rely on physicians


Physician-Led Expertise
Unlike most genetic testing services that rely on software engineers and automated reports, our interpretation is led by physicians trained in clinical genomics. We connect your DNA results to your symptoms and your health history to provide real medical decision support.


Clinical Integration and Personalization
At MyGenePortal, we don’t just identify mutations — we interpret them in context. We evaluate the clinical relevance of each variant, generate genomic differential diagnoses, and prvide rationale for confirmatory laboratory tests, imaging, specialist referrals, and lifestyle changes based on your unique profile.


Proven Accuracy
Our analysis includes all ACMG-recommended actionable genes — a curated list of genetic variants identified by the American College of Medical Genetics and Genomics as medically significant. These genes are associated with conditions that are preventable or treatable if detected early, such as certain cancers, heart disorders, and metabolic diseases.


Clear, Actionable Results
We translate complex genetic data into simple, meaningful insights. Our reports include clear next steps — not vague summaries or variant lists and our AI tools allow for interactive exploration of data when desired.


Transparent Pricing
We offer competitive and clearly explained pricing options. No surprise fees, no hidden upsells. Visit our Pricing page to learn more.

How Do We Compare to Other Labs?

Most sequencing companies provide a list of gene variants and a disclaimer. We provide something more — a physician-reviewed medical report that fits into your care. Here’s how we compare:
How do we compare to other labs?

Clients & Partners

Western university of health sciences logo
University of Lincoln logo
World Association of genomic medicine logo
American Pharmacogenomics Association logo
American Pharmacogenomics Association

DISCLAIMER

MoodNote and MyGenePortal.com are not healthcare providers. The content on MyGenePortal.com is intended only for educational and informational purposes and should not be used to diagnose, treat, or prevent any medical, psychological, or psychiatric condition.
The DNA‐variant interpretations presented here are not a substitute for professional medical advice. Only a licensed healthcare provider, after a direct and comprehensive clinical evaluation, can make medical diagnoses or recommend appropriate care.
If you have any health concerns, please consult a qualified healthcare professional licensed in your jurisdiction. In case of a medical emergency or if you are experiencing suicidal thoughts, dial 911 (in the U.S. or Canada) or go to your nearest emergency department immediately.

MyGenePortal is operated by MoodNote LLC, a U.S.-based provider of Clinically Validated genomic interpretation services.

Copyright © 2025 MoodNote LLC – All Rights Reserved

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